COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with melphalan

Bankruptcy models are used to assess credit risk and predict financial situation to indicate the probable bankruptcy of the company.Contribution deals with the application of chosen bankruptcy models in analysing and predicting the financial health of selected companies.Most of the models have been developed abroad.In case of Slovak Republic, its a

One of the characteristics of developed economies in the world is a very rich and diversified offer of goods.There are many products of different assortment, of different quality and price on the market.In keeping with the marketing conception, the production is trying to satisfy all potential consumers.Croatian freshwater fish farming has not yet